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Cat No. | Product Name | Synonyms | Targets |
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T10984 | DDR-TRK-1 | Discoidin Domain Receptor (DDR) | |
DDR-TRK-1 is a selective discoid domain receptor 1 (DDR1) inhibitor with IC50 value of 9.4 nM. DDR-TRK-1 also inhibits the TRK family. | |||
T72931 | TRK/ALK-IN-1 | ||
TRK/ALK-IN-1 is a potent dual inhibitor of TRK and ALK, exhibiting good correlation between its enzymatic inhibition and anti-proliferative activities, with IC50 values of 2.2 nM for TRKA, 9.3 nM for ALK WT, and 38 nM fo... | |||
T72289 | Type II TRK inhibitor 1 | Trk receptor | |
Type II TRK Inhibitor 1 is a potent inhibitor targeting multiple tropomyosin receptor kinase (TRK) fusion protein variants as well as the wild type. It demonstrates notable antiproliferative effects on Ba/F3 cells expres... | |||
T73033 | TRK II-IN-1 | Trk receptor | |
TRK II-IN-1 is a potent type II inhibitor of tropomyosin receptor kinases (TRK), demonstrating inhibitory half-maximal inhibitory concentrations (IC50s) of 3.3, 6.4, 4.3, and 9.4 nM against TRKA, TRKB, TRKC, and the muta... | |||
T6712 | Tyrphostin AG 879 | AG 879 | Apoptosis , EGFR , Trk receptor , HER , PDGFR |
Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR. | |||
T4349 | Sitravatinib | MG516,MGCD516 | Discoidin Domain Receptor (DDR) , VEGFR , FLT , Trk receptor , TAM Receptor , c-Kit , Ephrin Receptor |
Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and Axl. | |||
T19649 | PF-06273340 | PF 6273340,PF 06273340,PF6273340,PF-6273340 | Trk receptor |
PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflu... | |||
T3678 | Entrectinib | RXDX-101,NMS-E628 | Trk receptor , ROS , ALK , Autophagy , ROS Kinase |
Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C-ros oncogene 1 (ROS1; IC50: 0.2 nM). Entrectini... | |||
T61246 | TRK-IN-15 | ||
TRK-IN-15 (WO2012034091A1, compound X-55) is a highly effective inhibitor of TRK, a protein kinase with crucial involvement in the regulation of cellular growth, differentiation, and signal transduction. Offering signifi... | |||
T31234 | DDR-TRK-1N | DDR-TRK1N,DDRTRK-1N,DDRTRK1N,DDR-TRK 1N,DDR TRK-1N | |
DDR-TRK-1N is a negative control for DDR-TRK-1. | |||
T61443 | Trk-IN-7 | ||
Trk-IN-7 (compound I-6) is a highly potent inhibitor of TRK, exhibiting IC50 values ranging from 0.25-10 nM for TRKA, TRKB, and TRKC, respectively. In addition, Trk-IN-7 demonstrates notable inhibition against EML4-ALK (... | |||
T61247 | TRK-IN-16 | ||
TRK-IN-16 (WO2012034091A1, compound X-21) is a highly effective TRK inhibitor, targeting protein kinases that are integral to regulating cell growth, differentiation, and various cellular signal transduction processes. ... | |||
T61872 | Trk-IN-10 | ||
Trk-IN-10 (Compound 14j) is a highly effective inhibitor of TRK, with an IC50 of 0.86 nM against TrkA and 6.92 nM against TrkA G595R. As an RTK, Trk plays a crucial role as a drug target in solid tumors. Trk-IN-10 (IC50 ... | |||
T61551 | Trk-IN-20 | ||
Trk-IN-20 is a 3-vinylindazole derivative compound that effectively inhibits the functions of Trk kinases. It accomplishes this by suppressing the phosphorylation of TrkA, TrkB, and TrkC, with IC50 values of 1.6 nM, 2.9 ... | |||
T61712 | Trk-IN-8 | ||
Trk-IN-8, a powerful TRK inhibitor, demonstrates excellent potency against TRKAa, TRKA(G595R), and TRKC(G623R) with IC50 values of 0.42 nM, 0.89 nM, and 1.5 nM, respectively (WO2021115401A1, compound 3) [1]. | |||
T79125 | Protein kinase inhibitor 5 | Trk receptor | |
Protein kinase inhibitor 5 is a potent inhibitor of TRK-A, demonstrating an IC50 of 1.8 nM, and effectively suppresses cell viability [1]. | |||
T79126 | Protein kinase inhibitor 5 sulfate hydrate | Trk receptor | |
Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 nM and impairs cell viability [1]. | |||
T62531 | TRK-IN-12 | ||
TRK-IN-12 (Compound 9e), a macrocyclic derivative, is a potent TRK inhibitor, with efficacy against TRK G595R (IC 50 = 13.1 nM). It demonstrates significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (I... | |||
T78968 | TRK-IN-23 | Trk receptor | |
TRK-IN-23 (compound 24b) is a potent, orally active inhibitor of TRK with IC50s of 0.5 nM for TRKA, 9 nM for TRKC, 14 nM for TRKA G595R, 4.4 nM for TRKA F589L, and 4.8 nM for TRKA G667C. It induces apoptosis in Ba/F3-TRK... | |||
T79706 | TRK-IN-24 | Trk receptor | |
TRK-IN-24 (compound 10g) is a selective inhibitor of Trk receptors, effectively targeting TRKA, TRKC, and mutant forms TRKA G595R, TRKA G667C, and TRKA F589L, with IC50 values of 5.21, 4.51, 6.77, 1.42, and 6.13 nM, resp... | |||
T83433 | 1D228 | c-Met/HGFR | |
1D228, a c-Met/TRK inhibitor with antitumor properties, suppresses cyclin D1 to precipitate G0/G1 arrest, thereby inhibiting proliferation and migration of cancer cells. This compound is applicable in researching gastric... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01084 | TrkA Protein, Human, Recombinant (His) | Human | HEK293 Cells |
TrkA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.5 kDa and the accession number is P04629-1. | |||
TMPY-01760 | TrkA Protein, Human, Recombinant (aa 194-413, His) | Human | HEK293 Cells |
TrkA Protein, Human, Recombinant (aa 194-413, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P04629-1. | |||
TMPY-01759 | TrkA Protein, Human, Recombinant (aa 285-413, His) | Human | E. coli |
TrkA Protein, Human, Recombinant (aa 285-413, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 15.1 kDa and the accession number is P04629-1. | |||
TMPY-01083 | TrkA Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells |
TrkA Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 66 kDa and the accession number is P04629-1. | |||
TMPK-00774 | TrkA Protein, Human, Recombinant (aa 33-417, His) | Human | HEK293 Cells |
TrkA, a tyrosine kinase receptor, is an essential component of the nerve growth factor (NGF) response pathway. The binding of NGF to the receptor induces receptor autophosphorylation and activation of intracellular signa... | |||
TMPY-03536 | TrkA Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
TrkA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.7 kDa and the accession number is Q3UFB7. | |||
TMPY-03470 | TrkA Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
TrkA Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 69.2 kDa and the accession number is Q3UFB7. | |||
TMPY-04451 | AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 160 kDa and the accession number is P54619-1&Q9Y478-1&... | |||
TMPY-03878 | Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) | Human | HEK293 Cells |
Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 190.4 kDa and the accession number is P06756-1&P18564-1. | |||
TMPY-02501 | CD3D & CD3E Heterodimer Protein, Human, Recombinant | Human | HEK293 Cells |
CD3D & CD3E Heterodimer Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 77.5 kDa and the accession number is P04234-1&P07766-1. | |||
TMPY-03745 | CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) | Human | HEK293 Cells |
CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 31.05 kDa and the accession number is P04234-1&P07766-1. | |||
TMPY-03958 | TGF alpha Protein, Human, Recombinant | Human | E. coli |
The miR-137 served as a tumor suppressor in non-small cell lung cancer (NSCLC) and its suppressive effect is mediated by repressing TGFA expression. TGFA gene expression was significantly higher in tumor tissues compared... | |||
TMPY-04069 | Neurotrophin 3 Protein, Human, Recombinant | Human | E. coli |
NTF3 (Neurotrophin 3) is a Protein Coding gene. The protein encoded by this gene is a member of the neurotrophin family, that controls the survival and differentiation of mammalian neurons. This protein is closely relate... | |||
TMPY-02907 | FGF-19 Protein, Human, Recombinant | Human | E. coli |
FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, inclu... | |||
TMPY-05016 | HHLA2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
HHLA2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.4 kDa and the accession number is Q9UM44-1. | |||
TMPY-00654 | ACVR2B Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
ACVR2B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.0 kDa and the accession number is Q13705-1. | |||
TMPY-02361 | VEGFR2/KDR Protein, Human, Recombinant (His) | Human | HEK293 Cells |
VEGFR2/KDR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.6 kDa and the accession number is P35968-1. | |||
TMPY-02099 | CD63 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
CD63 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13 kDa and the accession number is P08962-1. | |||
TMPY-02813 | ErbB4 Protein, Human, Rhesus, Recombinant (His) | Human,Rhesus | HEK293 Cells |
ErbB4 Protein, Human, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.1 kDa and the accession number is Q15303-1. | |||
TMPY-04957 | PD-L2 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
PD-L2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is Q9BQ51-1. | |||
TMPY-04925 | CD8 beta Protein, Human, Recombinant, Biotinylated | Human | HEK293 Cells |
CD8 beta Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 17.6 kDa and the accession number is P10966-1. | |||
TMPY-03481 | IL-1R2 Protein, Human, Recombinant | Human | HEK293 Cells |
IL-1R2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 38.4 kDa and the accession number is P27930-1. | |||
TMPY-03363 | C-Reactive Protein Protein, Human, Recombinant | Human | HEK293 Cells |
C-Reactive Protein Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 23 kDa and the accession number is P02741-1. | |||
TMPY-03383 | IL-7 Protein, Human, Recombinant | Human | E. coli |
IL-7 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P13232-1. | |||
TMPY-00399 | HER3/ERBB3 Protein, Human, Recombinant | Human | HEK293 Cells |
HER3/ERBB3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 69.3 kDa and the accession number is P21860-1. | |||
TMPK-01151 | MXRA8 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses. MXRA8 Protein, Human, Recombinant (His) is expressed in ... | |||
TMPY-05493 | LIFR Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
LIFR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 116.1 kDa and the accession number is P42702-1. | |||
TMPK-00369 | HGF Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Hepatocyte growth factor (HGF) is an important component of the pathophysiology of IR, with increased levels in most common IR conditions, including obesity. HGF has a role in the metabolic flux of glucose in different i... | |||
TMPY-01283 | Glypican 3/GPC3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Glypican 3/GPC3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62 kDa and the accession number is P51654-1. | |||
TMPY-01065 | GM-CSFR alpha Protein, Human, Recombinant (His) | Human | HEK293 Cells |
GM-CSFR alpha Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36 kDa and the accession number is P15509-1. | |||
TMPK-00114 | C-Reactive Protein /CRP Protein, Human, Recombinant (His) | Human | HEK293 Cells |
C-reactive protein (CRP) is a polypeptide molecule belonging to the family of pentraxins. CRP is synthesized primarily by the liver in response to certain pro-inflammatory cytokines. It plays an important role in innate ... | |||
TMPY-01936 | VEGFR3/FLT4 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
VEGFR3/FLT4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.4 kDa and the accession number is P35917-1. | |||
TMPY-00586 | CLEC-2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
CLEC-2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9JL99-1. | |||
TMPY-00699 | CD155/PVR Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
CD155/PVR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.8 kDa and the accession number is P15151-1. | |||
TMPY-03762 | E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 87.1 kDa and the accession number is P12830-1. | |||
TMPY-06077 | LILRA1/LIR-6/CD85i Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
LILRA1/LIR-6/CD85i Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 75.3 kDa and the accession number is O75019-1. | |||
TMPK-00383 | ACE2/ACEH Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angio... | |||
TMPY-01459 | TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His) | Human | HEK293 Cells |
TNFR1/CD120a/TNFRSF1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.7 kDa and the accession number is P19438-1. | |||
TMPY-01827 | CD30/TNFRSF8 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
CD30/TNFRSF8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P28908-1. | |||
TMPY-01776 | Carboxylesterase 2/CES2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Carboxylesterase 2/CES2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60.4 kDa and the accession number is O00748-1. | |||
TMPY-02019 | CD59 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
CD59 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 10.2 kDa and the accession number is P13987-1. | |||
TMPY-01461 | EMAP-II/AIMP1 Protein, Human, Recombinant (His) | Human | E. coli |
EMAP-II/AIMP1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 35 kDa and the accession number is Q12904-1. | |||
TMPY-00972 | FGFR2 Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells |
FGFR2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 67.6 kDa and the accession number is P21802-1. | |||
TMPY-01104 | Coagulation factor XI/F11 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the p... | |||
TMPY-01912 | Cadherin 17/CDH17 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cadherin 17/CDH17 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 87 kDa and the accession number is Q12864-1. | |||
TMPY-02031 | B7-H3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
B7-H3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48 kDa and the accession number is Q5ZPR3-1. | |||
TMPY-02525 | RGMA Protein, Human, Recombinant (His) | Human | HEK293 Cells |
RGMa, also known as RGM domain family, member A, belongs to the RGM (repulsive guidance molecule) family whose members are membrane-associated glycoprotein. RGMa is a glycosylphosphatidylinositol-anchored glycoprotein th... | |||
TMPY-04262 | B7-H3 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
B7-H3 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48 kDa and the accession number is Q5ZPR3-1. | |||
TMPY-00915 | Serpin A1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Serpin A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is P01009-1. | |||
TMPY-02836 | MFGE8 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
MFGE8 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 42 kDa and the accession number is Q08431-1. | |||
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